Antibacterial resistance patterns in Streptococcus pneumoniae isolated from elderly patients: PROTEKT years 1-5 (1999-2004)


CANTON R., ÜNAL S. , FARRELL D. J.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol.30, no.6, pp.546-550, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1016/j.ijantimicag.2007.07.025
  • Title of Journal : INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
  • Page Numbers: pp.546-550

Abstract

The antibacterial susceptibilities of 6646 Streptococcus pneumoniae isolates collected in 38 countries from patients >= 65 years of age with community-acquired respiratory tract infections (RTIs) during years 1-5 of the PROTEKT study (1999-2004) were analysed. Rates of erythromycin resistance (36.0%), penicillin non-susceptibility (31.3%; 20.2% resistant plus 11.1% intermediately susceptible) and resistance to multiple antibacterials (37.2%) were stable over the 5 years. The most common macrolide resistance mechanism was erm(B) (61.4%); erm(B) + mef(A) strains increased from 5.4% (year 1) to 7.4% (year 5) (P = 0.037). Overall, 37.2% of isolates exhibited resistance to two or more antibacterials, including 15.9% resistant to both penicillin and erythromycin. Antibacterial resistance was highest in the Far East. Telithromycin resistance was rare (0.12%). Appropriate alternative empirical first-line therapies may be required for treating community-acquired RTIs in the elderly. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.