Immunogenicity of hepatitis a vaccine in children with cancer


Koksal Y., Yalcin B. , AYDIN G. B. , Sari N., Yazici N. , Varan A., ...More

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.23, no.8, pp.619-624, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1080/08880010600907239
  • Title of Journal : PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Page Numbers: pp.619-624

Abstract

This study evaluated the immuned response of the hepatitis A vaccine in children with cancer who were receiving chemotherapy. Twenty-eight patients with lymphomas or solid tumors and who had negative serology for hepatitis A were enrolled. The median age was 4.7 years (range 2-16). The patients received 1440 IU hepatitis A vaccine at 0 and 6 months. Seroconversion rates at the first and seventh months were 60% (n = 17/28 patients) and 89% (n = 24/27 patients). No adverse effects were observed. The hepatitis A vaccine was found to be effective and safe in children with cancer.