Immunogenicity of hepatitis a vaccine in children with cancer

Koksal Y., Yalcin B. , AYDIN G. B. , Sari N., Yazici N. , Varan A., ...Daha Fazla

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.23, sa.8, ss.619-624, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 8
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/08880010600907239
  • Sayfa Sayıları: ss.619-624


This study evaluated the immuned response of the hepatitis A vaccine in children with cancer who were receiving chemotherapy. Twenty-eight patients with lymphomas or solid tumors and who had negative serology for hepatitis A were enrolled. The median age was 4.7 years (range 2-16). The patients received 1440 IU hepatitis A vaccine at 0 and 6 months. Seroconversion rates at the first and seventh months were 60% (n = 17/28 patients) and 89% (n = 24/27 patients). No adverse effects were observed. The hepatitis A vaccine was found to be effective and safe in children with cancer.