Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis

Efe, Cumali; Hagstrom, Hannes; Ytting, Henriette; Bhanji, Rahima; Muller, Niklas; Wang, Qixia; PÜRNAK, TUĞRUL; Muratori, Luigi; Werner, Marten; Marschall, Hanns-Ulrich; Muratori, Paolo; GÜNŞAR, FULYA; Klintman, Daniel; Pares, Albert; Heurgue-Berlot, Alexandra; Schiano, Thomas; Cengiz, MUSTAFA; Tana, Michele; Ma, Xiong; Montano-Loza, Aldo; Berg, Thomas; Verma, Sumita; Larsen, Fin; Ozaslan, Ersan; Heneghan, Michael; Yoshida, Eric; Wahlin, Staffan

doi:10.1016/j.cgh.2017.06.001

Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis

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Efe C., Hagstrom H., Ytting H., Bhanji R. A., Muller N. F., Wang Q., ...More

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, vol.15, no.12, pp.1950-1957, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 15 Issue: 12
Publication Date: 2017
Doi Number: 10.1016/j.cgh.2017.06.001
Journal Name: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1950-1957
Hacettepe University Affiliated: Yes

Abstract

BACKGROUND & AIMS: Predniso(lo) ne, alone or in combination with azathioprine, is the standard-of-care (SOC) therapy for autoimmune hepatitis (AIH). However, the SOC therapy is poorly tolerated or does not control disease activity in up to 20% of patients. We assessed the efficacy of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy for patients with AIH.