Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering


Cinbiz M. N. , Tigli R. S. , Beskardes I. G. , GÜMÜŞDERELİOĞLU M. , ÇOLAK U.

JOURNAL OF BIOTECHNOLOGY, cilt.150, sa.3, ss.389-395, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 150 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jbiotec.2010.09.950
  • Dergi Adı: JOURNAL OF BIOTECHNOLOGY
  • Sayfa Sayıları: ss.389-395

Özet

In this study, computational fluid dynamics (CFD) analysis of a rotating-wall perfused-vessel (RWPV) bioreactor is performed to characterize the complex hydrodynamic environment for the simulation of cartilage development in RWPV bioreactor in the presence of tissue-engineered cartilage constructs, i.e., cell-chitosan scaffolds. Shear stress exerted on chitosan scaffolds in bioreactor was calculated for different rotational velocities in the range of 33-38 rpm. According to the calculations, the lateral and lower surfaces were exposed to 0.07926-0.11069 dyne/cm(2) and 0.05974-0.08345 dyne/cm(2), respectively, while upper surfaces of constructs were exposed to 0.09196-0.12847 dyne/cm(2). Results validate adequate hydrodynamic environment for scaffolds in RWPV bioreactor for cartilage tissue development which concludes the suitability of operational conditions of RWPV bioreactor. (C) 2010 Elsevier B.V. All rights reserved.