Correlation of flow cytometric parameters and transferrin receptors with gallium-67 scintigraphic images in lymphoma patients


Kiratli P., Canpinar H., Ruacan S., Kansu E.

NUCLEAR MEDICINE COMMUNICATIONS, vol.21, no.10, pp.925-931, 2000 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 10
  • Publication Date: 2000
  • Doi Number: 10.1097/00006231-200010000-00006
  • Title of Journal : NUCLEAR MEDICINE COMMUNICATIONS
  • Page Numbers: pp.925-931

Abstract

The purpose of this study was to determine the correlation of flow cytometric parameters and transferrin receptors with gallium-67 scintigraphic imaging results in Hodgkin's and non-Hodgkin's lymphoma patients. DNA content and cell cycle analyses were performed using flow cytometry and transferrin receptor analysis was carried out by the immunohistochemistry technique in 24 patients aged between 16 and 62 years. All patients underwent gallium-67 scintigraphy, and tumour to background ratios were calculated. The findings were correlated with computed tomography and/or magnetic resonance imaging. A strong relationship was observed between flow cytometry and transferrin receptor expression with gallium-67 tumour scintigraphy [P = 0.005, r = 0.054 and P = 0.038, r = 0.54 (Spearman test), respectively]. The results of this study show that there is a close correlation between each of these modalities and, as they reflect the biological activity of the tumour, together they have a major role in treatment and follow-up. ((C) 2000 Lippincott Williams & Wilkins).