ADVANCED PHASE CHRONIC MYELOID LEUKEMIA RESISTANT TO IMATINIB, NILOTINIB, DASATINIB AND INTERFERON WITHOUT ABL KINASE MUTATION

Malkan Ü. Y., Gunes G., Eliacik E., Isik A., Sayinalp N., Aksu S.

5th International Eurasian Hematology Congress, Antalya, Turkey, 15 - 19 October 2014, vol.38 identifier identifier

  • Publication Type: Conference Paper / Summary Text
  • Volume: 38
  • Doi Number: 10.1016/s0145-2126(14)70079-7
  • City: Antalya
  • Country: Turkey
  • Keywords: advanced phase chronic myeloid leukemia, resistant, without abl kinase mutation
  • Hacettepe University Affiliated: Yes

Abstract

We study multi-peak solitons \textit{on a plane-wave background} in an erbium-doped fiber system with some higher-order effects, which is governed by a coupled Hirota and Maxwel-Bloch (H-MB) model. The important characteristics of multi-peak solitons induced by the higher-order effects, such as the velocity changes, localization or periodicity attenuation, and state transitions, are revealed in detail. In particular, our results demonstrate explicitly that a multi-peak soliton can be converted to an anti-dark soliton when the periodicity vanishes; on the other hand, a multi-peak soliton is transformed to a periodic wave when the localization vanishes. Numerical simulations are performed to confirm the propagation stability of multi-peak solitons riding on a plane-wave background. Finally, we compare and discuss the similarity and difference of multi-peak solitons in special degenerate cases of the H-MB system with general existence conditions.