Akademik Veri Yönetim Sistemi
HIV MEDICINE, cilt.26, sa.11, ss.1739-1747, 2025 (SCI-Expanded, Scopus)
Introduction Monitoring transmitted drug resistance is crucial for guiding first-line antiretroviral therapy (ART) and controlling the rising HIV epidemic in T & uuml;rkiye. This study aimed to determine the prevalence of transmitted antiretroviral resistance to protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase strand transfer inhibitors (INSTIs) and capsid assembly inhibitors (CAIs). We also assessed the distribution of HIV-1 subtypes and circulating recombinant forms (CRFs) at one of the main national referral centres in T & uuml;rkiye.Methods We included 104 consecutive ART-na & iuml;ve people living with HIV who presented at Hacettepe University Hospital in Ankara between November 2021 and November 2022. Demographic data, probable transmission routes and geographic origins were recorded. HIV-1 genotyping was performed to identify subtypes and resistance-associated mutations using standard methods.Results Of the 104 individuals, 97 were from 25 different cities in T & uuml;rkiye, while 7 originated from 5 different countries. The most probable transmission routes were men who have sex with men (MSM) (64.42%), heterosexual contact (30.77%) and unknown (4.81%). Resistance-associated mutations were detected in 14.42% of individuals. Resistance rates were 1.92% for PI, 4.80% for NRTI and 7.69% for NNRTI. No resistance mutations were found against INSTI or CAI.Conclusion Transmitted resistance to PI, NRTI and NNRTI remains present in T & uuml;rkiye, though at moderate levels. The absence of resistance to INSTI and CAI supports their potential utility as effective components of treatment regimens in T & uuml;rkiye.