Expression of TAP73 and Delta NP73 in malignant gliomas


Ugur H., Sayan A., Ozdamar S., Kanpolat Y., Ozturk M.

ONCOLOGY REPORTS, cilt.11, sa.6, ss.1337-1341, 2004 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 11 Konu: 6
  • Basım Tarihi: 2004
  • Dergi Adı: ONCOLOGY REPORTS
  • Sayfa Sayıları: ss.1337-1341

Özet

The p73 gene is able to encode transcriptionaly active TAp73, as well as a dominant-negatively acting DeltaNp73 transcript isoforms. We studied differential expression of these forms in normal brain as well as glial tumors, by semiquantitative RT-PCR. The expression of p73 was low or undetectable in normal brain tissues. Most of the tumors and non-tumor brain tissues also lacked significant expression of p73 in patients with low-grade astrocytomas. In contrast, most high-grade glial tumors displayed strong upregulation of TAp73, whereas only a few displayed DeltaNp73 expression. These aberrations may reflect the inactivation of retinoblastoma pathway in these tumors which result in the activation of E2F transcription factors, since TAp73 is a known target of E2F1 gene. The study of TAp73 expression in brain tumors may serve as a means to evaluate the retinoblastoma pathway-dependent tumor progression.