Professionals agree that book characters can be excellent role models for young children. Therefore, analyzing children's literature portraying impairments provides valuable information for educators, parents, siblings, extended family members and librarians. In this study, forty-six picture books are analyzed in order to determine the relationships between the characters with and without physical and sensory impairments. The role of each character and the type of their relationship are analyzed in every occasion in which characters with and without physical and sensory impairments are involved in each story. The data analysis indicates eleven different relationship categories showing positive, neutral or negative portrayals. The results of the study imply that story characters change over time through their interactions in characters with impairments. The present study concludes that children's literature contains significant promise with respect to helping children develop friendships by learning about and accepting individual differences. Interpretations of the findings were discussed and implications for practice were presented.