Aquaporin-4 expression is not elevated in mild hydrocephalus

Aghayev K., Bal E., Rahimli T., Mut M., Balci S., Vrionis F., ...More

Acta Neurochirurgica, vol.154, no.4, pp.753-759, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 154 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1007/s00701-011-1241-9
  • Journal Name: Acta Neurochirurgica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.753-759
  • Hacettepe University Affiliated: Yes


Aquaporin-4 (aqp-4) is a member of water channel family proteins primarily expressed in the central nervous system. Physiologically it is the main channel providing water transport into the nervous system water compartments and across the blood-brain barrier. Several studies demonstrated its compensatory role in severe hydrocephalus. However, its role is not clear during the initial stages of hydrocephalus.