Aquaporin-4 expression is not elevated in mild hydrocephalus

Aghayev K., Bal E., Rahimli T., Mut M. , Balci S., Vrionis F., ...More

Acta Neurochirurgica, vol.154, no.4, pp.753-759, 2012 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 154 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1007/s00701-011-1241-9
  • Title of Journal : Acta Neurochirurgica
  • Page Numbers: pp.753-759


Aquaporin-4 (aqp-4) is a member of water channel family proteins primarily expressed in the central nervous system. Physiologically it is the main channel providing water transport into the nervous system water compartments and across the blood-brain barrier. Several studies demonstrated its compensatory role in severe hydrocephalus. However, its role is not clear during the initial stages of hydrocephalus.