Increased Serum Nesfatin-1 Levels in Patients with Impaired Glucose Tolerance

Akin S., Gulcelik N. E., Aksoy D. Y., Karakaya J., Usman A.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol.21, no.3, pp.65-67, 2017 (ESCI) identifier identifier


Purpose: Nesfatin-1 is a recently discovered energy-regulating peptide, widely expressed in both central and peripheral tissues. It is involved in various functions, such as the stimulation of hypothalamic-pituitary-adrenal axis and sympathetic nervous system, influencing visceral functions, water intake, and regulation of temperature and emotions. It exerts a direct glucose-dependent insulinotropic action on the beta cells of pancreatic islets. The current study evaluated nesfatin-1 levels and insulin response to glucose load in patients with impaired glucose tolerance (IGT) and in healthy subjects.