Vancomycin containing PLLA/beta-TCP controls experimental osteomyelitis in vivo

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Kankilic B., BİLGİÇ E., KORKUSUZ P., KORKUSUZ F.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, vol.9, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2014
  • Doi Number: 10.1186/s13018-014-0114-3
  • Journal Name: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Bone, Osteomyelitis, Drug delivery, Rat, Vancomycin, PLLA, beta-TCP, MRSA, Infection, TRICALCIUM PHOSPHATE COMPOSITES, POLY-EPSILON-CAPROLACTONE, IMPLANTS, RELEASE, MODEL, VITRO, INFECTIONS, KINETICS, DELIVERY, RATS
  • Hacettepe University Affiliated: Yes

Abstract

Background: Implant-related osteomyelitis (IRO) is recently controlled with local antibiotic delivery systems to overcome conventional therapy disadvantages. In vivo evaluation of such systems is however too little.