Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients


ERDEM B. , KUCUKYILDIRIM S., Saglar E. , POLAT Z., MERGEN H.

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.25, no.5, pp.512-517, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.5152/tjg.2014.4791
  • Title of Journal : TURKISH JOURNAL OF GASTROENTEROLOGY
  • Page Numbers: pp.512-517

Abstract

Background/Aims: Cancer is a consequence of the disruption of cellular regulation. Epigenetic is one of the reasons of this disruption. Epigenetic factors play a role in the carcinogenesis by affecting proto-oncogenes and tumor suppressor genes and it is one of the most popular research areas in recent years. DNA methylation, which is an epigenetic mechanism, occurs in the early stages of tumorigenesis. Promoter methylation which causes the silence of tumor suppressor genes have been studied extensively in various tumor types. The aim of this study was to investigate promoter methylation of certain tumor suppressor genes, Cyclin-dependent kinase inhibitor 2A (p16) and Adenomatous polyposis coli (APC), which take part in gastrointestinal tumorigenesis.