ObjectiveThe aim was to compare the clinical performance of uncoated and adhesive precoated brackets bonded with either self-etching primer (SEP) or conventional two-step etch and primer method (CEM).Subjects and methodsThe sample consisted of 63 patients with a mean age of 15.201.6years. In group I (n=15), uncoated brackets and CEM; in group II (n=16), precoated brackets and CEM; in group III (n=16), uncoated brackets and SEP; in group IV (n=16), precoated brackets and SEP were used for bonding. Bonding time, bracket failure rate, and adhesive remnant index (ARI) scores were measured. The mean orthodontic treatment time was 1.130.18years. One-way variance ANOVA was used to determine bonding time differences and the chi-square test was used to determine differences in bracket failure rates and ARI scores.ResultsThe bonding time was significantly lower for Groups III and IV, when compared to Groups I and II (p<0.001). The bond failure rates were not different between the groups. Significant difference was observed between the procedures in relation to ARI scores (p<0.001), which were higher in group IV.Conclusions p id=Par4 Precoated brackets with SEP application significantly reduced chair time without compromising bracket failure rate.Clinical relevance p id=Par5 Precoated brackets with SEP application can be safely used for bonding. Regarding the mode of failure, this group can be thought as favorable with a reduced risk of enamel tear.