Polymorphisms of endotoxin pathway and endotoxin exposure: in vitro IgE synthesis and replication in a birth cohort


ŞAHİNER Ü. M. , Semic-Jusufagic A., Curtin J. A. , BİRBEN E. , Belgrave D., SACKESEN C. , ...Daha Fazla

ALLERGY, cilt.69, sa.12, ss.1648-1658, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 69 Konu: 12
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/all.12504
  • Dergi Adı: ALLERGY
  • Sayfa Sayıları: ss.1648-1658

Özet

BackgroundGenetic variants in endotoxin signaling pathway are important in modulating the effect of environmental endotoxin on asthma and atopic phenotypes. Our objective was to determine the single nucleotide polymorphisms (SNPs) in the endotoxin signaling pathway that may influence in vitro IgE synthesis and to investigate the relationship between these variants and endotoxin exposure in relation to the development of asthma and atopy in a birth cohort.