Polymorphisms of endotoxin pathway and endotoxin exposure: in vitro IgE synthesis and replication in a birth cohort

ŞAHİNER, ÜMİT; Semic-Jusufagic, A.; Curtin, J.; BİRBEN, ESRA; Belgrave, D.; SACKESEN, CANSIN; Simpson, A.; YAVUZ, T.; AKDIS, C.; Custovic, A.; KALAYCI, O.

doi:10.1111/all.12504

Polymorphisms of endotoxin pathway and endotoxin exposure: in vitro IgE synthesis and replication in a birth cohort

Atıf İçin Kopyala

ŞAHİNER Ü. M., Semic-Jusufagic A., Curtin J. A., BİRBEN E., Belgrave D., SACKESEN C., ...Daha Fazla

ALLERGY, cilt.69, sa.12, ss.1648-1658, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 69 Sayı: 12
Basım Tarihi: 2014
Doi Numarası: 10.1111/all.12504
Dergi Adı: ALLERGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1648-1658
Anahtar Kelimeler: asthma, atopy, endotoxin, gene, IgE, CD14 GENE, SERUM IGE, ASTHMA, CHILDREN, ATOPY, ASSOCIATION, CHILDHOOD, CYTOKINE, CELLS, RISK
Hacettepe Üniversitesi Adresli: Evet

Özet

BackgroundGenetic variants in endotoxin signaling pathway are important in modulating the effect of environmental endotoxin on asthma and atopic phenotypes. Our objective was to determine the single nucleotide polymorphisms (SNPs) in the endotoxin signaling pathway that may influence in vitro IgE synthesis and to investigate the relationship between these variants and endotoxin exposure in relation to the development of asthma and atopy in a birth cohort.