Polymorphisms of endotoxin pathway and endotoxin exposure: in vitro IgE synthesis and replication in a birth cohort


ŞAHİNER Ü. M. , Semic-Jusufagic A., Curtin J. A. , BİRBEN E. , Belgrave D., SACKESEN C. , ...More

ALLERGY, vol.69, no.12, pp.1648-1658, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 12
  • Publication Date: 2014
  • Doi Number: 10.1111/all.12504
  • Title of Journal : ALLERGY
  • Page Numbers: pp.1648-1658
  • Keywords: asthma, atopy, endotoxin, gene, IgE, CD14 GENE, SERUM IGE, ASTHMA, CHILDREN, ATOPY, ASSOCIATION, CHILDHOOD, CYTOKINE, CELLS, RISK

Abstract

BackgroundGenetic variants in endotoxin signaling pathway are important in modulating the effect of environmental endotoxin on asthma and atopic phenotypes. Our objective was to determine the single nucleotide polymorphisms (SNPs) in the endotoxin signaling pathway that may influence in vitro IgE synthesis and to investigate the relationship between these variants and endotoxin exposure in relation to the development of asthma and atopy in a birth cohort.