Polymorphisms of endotoxin pathway and endotoxin exposure: in vitro IgE synthesis and replication in a birth cohort

ŞAHİNER Ü. M., Semic-Jusufagic A., Curtin J. A., BİRBEN E., Belgrave D., SACKESEN C., ...More

ALLERGY, vol.69, no.12, pp.1648-1658, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 12
  • Publication Date: 2014
  • Doi Number: 10.1111/all.12504
  • Journal Name: ALLERGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1648-1658
  • Keywords: asthma, atopy, endotoxin, gene, IgE, CD14 GENE, SERUM IGE, ASTHMA, CHILDREN, ATOPY, ASSOCIATION, CHILDHOOD, CYTOKINE, CELLS, RISK
  • Hacettepe University Affiliated: Yes

Abstract

BackgroundGenetic variants in endotoxin signaling pathway are important in modulating the effect of environmental endotoxin on asthma and atopic phenotypes. Our objective was to determine the single nucleotide polymorphisms (SNPs) in the endotoxin signaling pathway that may influence in vitro IgE synthesis and to investigate the relationship between these variants and endotoxin exposure in relation to the development of asthma and atopy in a birth cohort.