Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar


Musdal Y. , Mannervik B.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1850, sa.9, ss.1877-1883, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1850 Konu: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.bbagen.2015.05.015
  • Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Sayfa Sayıları: ss.1877-1883

Özet

Background:The genome of poplar (Populus trichocarpa) encodes 81 glutathione transferases (GSTs) annotated in eight distinct classes. The tau class is considered the most versatile in the biotransformation of xenobiotics and is composed of 58 GSTs. Two of the enzymes, GSTU16 and GSTU45, have particular interest since their expression is induced by exposure of poplar tissues to 2,4,6-trinitrotoluene (TNT) and could potentially be involved in the metabolism of this toxic environmental contaminant.