Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar

Musdal, YAMAN; Mannervik, Bengt

doi:10.1016/j.bbagen.2015.05.015

Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar

Atıf İçin Kopyala

Musdal Y., Mannervik B.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1850, sa.9, ss.1877-1883, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 1850 Sayı: 9
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.bbagen.2015.05.015
Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1877-1883
Hacettepe Üniversitesi Adresli: Hayır

Özet

Background:The genome of poplar (Populus trichocarpa) encodes 81 glutathione transferases (GSTs) annotated in eight distinct classes. The tau class is considered the most versatile in the biotransformation of xenobiotics and is composed of 58 GSTs. Two of the enzymes, GSTU16 and GSTU45, have particular interest since their expression is induced by exposure of poplar tissues to 2,4,6-trinitrotoluene (TNT) and could potentially be involved in the metabolism of this toxic environmental contaminant.