Exercise training reduces myocardial lipid peroxidation following short-term ischemia-reperfusion


Demirel H. , Powers S., Caillaud C., Coombes J., Naito H., Fletcher L., ...Daha Fazla

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, cilt.30, sa.8, ss.1211-1216, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 30 Konu: 8
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1097/00005768-199808000-00005
  • Dergi Adı: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
  • Sayfa Sayıları: ss.1211-1216

Özet

Purpose: The purpose of these experiments was to test the hypothesis that endurance exercise training will reduce myocardial lipid peroxidation following short-term ischemia and reperfusion (I-R). Methods: Female Sprague-Dawley rats (4 months old) were randomly assigned to either a sedentary control group (N = 13) or to an exercise training group (N = 13). The exercise trained animals ran 4 d . wk(-1) (90 min . d(-1)) at similar to 75% of (V) over dot O-2max. Following a 10-wk training program, animals were anesthetized, mechanically ventilated, and the chest was opened by thoracotomy. Coronary occlusion was achieved by a ligature around the left coronary artery; occlusion was maintained for 5 min followed by a 10-min period of reperfusion. Results: Although training did not alter (P > 0.05) myocardial activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase); training was associated with significant increases (P < 0.05) in heat shack protein (HSP72) in the left ventricle. Compared with controls, trained animals exhibited significantly lower levels (P < 0.05) of myocardial lipid peroxidation following I-R. Conclusions: These data support the hypothesis that exercise training provides protection against myocardial lipid peroxidation induced by short-term I-R in vivo.