According to the load theory of attention, an active cognitive control mechanism is needed to ensure that behaviour is controlled by target-relevant information when distractors are also perceived. Although the active cognitive control mechanism consists of working memory, cognitive flexibility, and inhibition components, predictions regarding the load effects of this mechanism were derived mostly from studies on working memory. We aimed to test whether these predictions are also valid for an inhibition component. The inhibitory load was manipulated physiologically by creating different bladder pressure and its effects on distractor interference were examined under low and high perceptual load conditions. The results indicated that the availability of inhibitory control resources was important for decreasing the interference of distractors in the low perceptual load condition and that the high perceptual load reduced the effects of distractors independently from the availability of inhibitory resources. The results were consistent with the predictions of load theory, and to the best of our knowledge, the study provided the first piece of evidence in terms of the load effect of inhibition component on distractor interference.