Ganoderma lucidum Polysaccharides as An Anti-cancer Agent


ŞÖHRETOĞLU D. , Huang S.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.5, ss.667-674, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871520617666171113121246
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.667-674

Özet

The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. Clinical studies have shown beneficial effects of G. lucidum as an alternative adjuvant therapy in cancer patients without obvious toxicity. G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts of this mushroom. Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic effects. Here, we briefly summarize these anticancer effects of GLP and the underlying mechanisms.