Synthesis and characterization of Fe3O4-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies

Dincer C. A., Yildiz N., Karakecili A., AYDOĞAN N., Calimli A.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.45, sa.7, ss.1408-1414, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/21691401.2016.1243546
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1408-1414
  • Anahtar Kelimeler: Fe3O4 nanoparticles, silane compounds, magnetic polymer nanocomposites, anticancer drug, IRON-OXIDE NANOPARTICLES, COATED MAGNETIC NANOPARTICLES, PLGA-BASED NANOPARTICLES, FE3O4 NANOPARTICLES, CANCER-THERAPY, DELIVERY, DOXORUBICIN, PACLITAXEL, CARRIERS, MICROSPHERES
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Magnetic nanocomposites (Fe3O4-MPTMS-PLGA) were synthesized by single oil emulsion method and characterized by transmission electron microscopy (TEM), X-Ray diffraction (XRD), and vibrating sample magnetometer (VSM). Particle size of nanocomposites was between 117 nm and 246 nm. High performance liquid chromatography (HPLC) was used to investigate drug loading (paclitaxel, PTX) and release from Fe3O4-MPTMS-PLGA-PTX nanocomposites. The percentages of drug loading and encapsulation efficiency onto nanocomposites were found as 7.35 and 68.58, respectively. Cytotoxities of free anticancer drug and anticancer drug-loaded nanocomposites were determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. In vitro cell culture studies indicated that Fe3O4-MPTMS-PLGA-PTX had significant toxicity on MG-63 cancer cells.