Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

ÖZGEN R., ŞÖHRETOĞLU D., Kuruüzüm-Uz A.

Journal of the Science of Food and Agriculture, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Review
  • Publication Date: 2026
  • Doi Number: 10.1002/jsfa.70609
  • Journal Name: Journal of the Science of Food and Agriculture
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, INSPEC
  • Keywords: enoki, enokitake, Flammulina velutipes, functional foods, polysaccharides
  • Hacettepe University Affiliated: Yes

Abstract

Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antitumor, immunomodulatory, and gut microbiota-regulating effects. These effects are primarily attributed to bioactive compounds such as polysaccharides, phenolic compounds, and sterols, and are mediated through the modulation of multiple signaling pathways, including NF-κB, MAPK, and PI3K/Akt. Collectively, the available evidence indicates that F. velutipes represents a promising candidate for the development of functional foods and pharmaceutical formulations. This review emphasizes its therapeutic potential and provides valuable insights to guide future medicinal research. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.