Biotechnology integrates bioscience and business fields with engineering sciences to create more efficient health industrial processes. This sector is knowledge-intensive and highly competitive with strict market regulations. This study aims to classify OECD countries in terms of biotechnology and bioentrepreneurship and quality of research development indicators. Data gathered from official statistics of 26 OECD countries. Two-step clustering analysis is applied by using biotechnology innovation, quality of scientific and high education indicators. Study findings emphasize that there exist two groups of countries which are developed and developing ones. United States plays a leading role in biotechnology innovation and bioentrepreneurship and it is a member of developed country group. University-industry collaboration and capacity for innovation are the most important predictors of country groups, respectively. Statistically significant mean rank differences observed between country groups in terms of number of biotechnology firms, expenditure for biotechnology research and development, number of patents for biotechnology, innovation capacity, quality of research institutions, university-industry collaboration, quality of mathematics and science education. University-industry collaboration is critical to improve innovation performance in biotechnology and to strengthen the triangle between investor, entrepreneur and biotechnology innovators.