Increased xanthine oxidase activity after traumatic brain injury in rats


Solaroglu I., Okutan O., Kaptanoglu E., Beskonakli E., Kilinc K.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.12, ss.273-275, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 12 Konu: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jocn.2004.12.002
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Sayfa Sayıları: ss.273-275

Özet

Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxiclation after TBI. In this study, we investigate the time-dependent changes in xanthine oxidase (XO) activity and lipid peroxiclation using a focal TBI animal model. We demonstrate that there is an immediate increase in lipid peroxiclation by-products and in XO enzyme activity after TBI. (c) 2005 Elsevier Ltd. All rights reserved.