Increased xanthine oxidase activity after traumatic brain injury in rats


Solaroglu I., Okutan O., Kaptanoglu E., Beskonakli E., Kilinc K.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.12, no.3, pp.273-275, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jocn.2004.12.002
  • Title of Journal : JOURNAL OF CLINICAL NEUROSCIENCE
  • Page Numbers: pp.273-275

Abstract

Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxiclation after TBI. In this study, we investigate the time-dependent changes in xanthine oxidase (XO) activity and lipid peroxiclation using a focal TBI animal model. We demonstrate that there is an immediate increase in lipid peroxiclation by-products and in XO enzyme activity after TBI. (c) 2005 Elsevier Ltd. All rights reserved.