Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, vol.114, no.4, pp.188-191, 2006 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 114 Issue: 4
- Publication Date: 2006
- Doi Number: 10.1055/s-2006-924064
- Journal Name: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.188-191
- Hacettepe University Affiliated: Yes
Abstract
The aim of the study is to investigate whether platelet activity is increased by hyperprolactinemia during pregnancy as reflected by beta-thromboglobulin level. Forty-eight healthy, pregnant, and 30 healthy, non-pregnant women were investigated with respect to platelet count, collagen/ADP and collagen/epinephrine closure times, beta-thromboglobulin and prolactin levels. The comparison of the variables between the two groups was made by Mann-Whitney U test. The correlation analyses were performed by Spearman's rank correlation test. Our results revealed that platelet counts, collagen/ADP and collagen/epinephrine closure times and beta-thromboglobulin showed no statistically significant differences between pregnant and non-pregnant women. We found no significant correlation between prolactin and collagen/ADP closure time (r=0.175), between prolactin and collagen/epinephrine closure time (r=-0.112) and between prolactin and beta-thromboglobulin (r=0.220) in pregnant women. Our findings suggest that platelet activity is comparable during pregnant and non-pregnant states and there is no significant effect of prolactin on platelet function in vivo as reflected by beta-thromboglobulin level.