Association of mean platelet volume level with in-hospital major adverse events in infective endocarditis

TOK D., Canpolat U., TOK D., TURAK O., ISLEYEN A., OKSUZ F., ...More

WIENER KLINISCHE WOCHENSCHRIFT, vol.127, pp.197-202, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 127
  • Publication Date: 2015
  • Doi Number: 10.1007/s00508-015-0746-2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.197-202
  • Hacettepe University Affiliated: No


We hypothesised that increased on-admission and follow-up mean platelet volume (MPV) levels would correlate with adverse outcomes in patients with infective endocarditis (IE). A total of 108 consecutive patients were grouped into two according to median MPV level (a parts per thousand currency signaEuro parts per thousand 8.6 and > 8.6 fL). Patients with MPV level of > 8.6 fL had a significantly higher rate of end-stage renal disease, Staphylococcus aureus infection, higher CRP levels, embolic events and in-hospital mortality compared to patients with MPV levels a parts per thousand currency signaEuro parts per thousand 8.6 fL. In multivariable Cox regression analysis, previous history of IE, S. aureus infection, end-stage renal disease, depressed LVEF, early surgical intervention, vegetation size a parts per thousand yenaEuro parts per thousand 10 mm, presence of perivalvular abscess, higher on-admission platelet count, CRP and MPV levels emerged as independent predictors of in-hospital unfavourable outcomes. Patients with embolic events and in-hospital mortality revealed an incremental trend for MPV levels compared to patients without any adverse events. Our study results suggest that both on-admission and follow-up MPV levels may be a simple and available biomarker for risk stratification of IE patients.