Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice


Lev D., Kim S., Onn A., Stone V., Nam D., Yazici S. , ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.11, ss.306-314, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 1
  • Basım Tarihi: 2005
  • Dergi Adı: CLINICAL CANCER RESEARCH
  • Sayfa Sayıları: ss.306-314

Özet

Purpose: Bone is a common site for breast cancer metastasis. Platelet-derived growth factor (PDGF) and PDGF receptors (PDGFR) are involved in the regulation of bone resorption. This study examined the effects of STI571 (imatinib mesylate), which inhibits PDGFR tyrosine kinase signaling, on the growth of human breast cancer cells in the bone of nude mice with consequent osteolysis.