Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice

Lev D., Kim S., Onn A., Stone V., Nam D., Yazici S., ...More

CLINICAL CANCER RESEARCH, vol.11, no.1, pp.306-314, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2005
  • Journal Name: CLINICAL CANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.306-314
  • Hacettepe University Affiliated: Yes

Abstract

Purpose: Bone is a common site for breast cancer metastasis. Platelet-derived growth factor (PDGF) and PDGF receptors (PDGFR) are involved in the regulation of bone resorption. This study examined the effects of STI571 (imatinib mesylate), which inhibits PDGFR tyrosine kinase signaling, on the growth of human breast cancer cells in the bone of nude mice with consequent osteolysis.