Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice

Lev D., Kim S., Onn A., Stone V., Nam D., Yazici S., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.11, sa.1, ss.306-314, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2005
  • Dergi Adı: CLINICAL CANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.306-314
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: Bone is a common site for breast cancer metastasis. Platelet-derived growth factor (PDGF) and PDGF receptors (PDGFR) are involved in the regulation of bone resorption. This study examined the effects of STI571 (imatinib mesylate), which inhibits PDGFR tyrosine kinase signaling, on the growth of human breast cancer cells in the bone of nude mice with consequent osteolysis.