The Ameliorative Effects of Pycnogenol (R) on Liver Ischemia-Reperfusion Injury in Rats

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Tokac M., BACANLI M., DUMLU E. G., AYDIN DİLSİZ S., Engin M., BOZKURT B., ...More

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.3, pp.257-263, 2017 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.4274/tjps.49369
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.257-263
  • Keywords: Pycnogenol, ischemia reperfusion injury, DNA damage, INDUCED OXIDATIVE DAMAGE, HEPATIC ISCHEMIA, DNA-DAMAGE, REACTIVE OXYGEN, ISCHEMIA/REPERFUSION INJURY, ANTIOXIDANT ACTIVITY, KUPFFER CELLS, DEXMEDETOMIDINE, MECHANISMS, EXTRACT
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: Pycnogenol (R) (PYC (R)), a standardized extract from the bark of Pinus maritima, consists of different phenolic compounds. PYC (R) has shown to have protective effects on chronic diseases such as diabetes, asthma, cancer, and immune disorders. The aim of this study was to determine the effects of PYC (R) against the DNA damage and biochemical changes in blood, liver, and lung tissues of ischemia-reperfusion (IR)-induced Wistar albino rats.