pH-sensitive hydrogels and applications in controlled drug delivery pH'ya duyarh hidrojeller ve kontrollu i̇laç salim sistemlerindeki uygulamalari


Basan H., Imren D., GÜMÜŞDERELİOĞLU M.

Fabad Journal of Pharmaceutical Sciences, vol.26, no.2, pp.81-92, 2001 (Refereed Journals of Other Institutions) identifier

  • Publication Type: Article / Review
  • Volume: 26 Issue: 2
  • Publication Date: 2001
  • Title of Journal : Fabad Journal of Pharmaceutical Sciences
  • Page Numbers: pp.81-92

Abstract

Hydrogels are defined as three-dimensional polymeric networks containing a considerable amount of water, e.g., more than 20%. Environmentally-sensitive hydrogels exhibit dramatic changes in their swelling behavior, network structure, permeability or mechanical strength in response to changes in the pH or ionic strength of the surrounding fluid, or temperature. Hydrogels exhibiting pH-dependent swelling behavior can be swollen from ionic networks. These ionic networks contain either acidic or basic pendant groups, pH-sensitive swelling can be exploited in the development of drug delivery systems, which Would release the drug in response to the pH of the surrounding solution, pH-sensitive hydrogels have a potential use in the site-specific delivery of drugs to specific regions of the gastrointestinal (GI) tract due to pH variations throughout the Gl tract, and for more complex systems where a physiological stimuli results in a change in pH and release of drug.