Dry eye syndrome is a multifactorial and prevalent ocular disease in elderly population that results in decrease quality of life. Dry eye syndrome is defined as a disease of tear film layer due to reduced tear production and/or tear film instability. Age-related alterations including eyelid laxity, meibomian gland disease and orifice metaplasia, decrease in tear volume result in dry eye. All ages may be suffered from Dry eye syndrome can be seen secondary to another eye diseases or systemic disease. This review will summarize the current knowledge about dry eye and therapeutic interventions being used to treat Dry eye syndrome.