Baicalein Nanofiber Scaffold Containing Hyaluronic Acid and Polyvinyl Alcohol: Preparation and Evaluation

Bachimam K., Emul E., SAĞLAM N., KORKUSUZ F.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.50, no.4, pp.1139-1146, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2001-123
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1139-1146
  • Keywords: Baicalein, hyaluronic acid, nanofiber, electrospinning, bone cancer, tissue engineering, BONE, DIFFERENTIATION, OSTEOSARCOMA, ACTIVATION, MIGRATION, DELIVERY
  • Hacettepe University Affiliated: Yes

Abstract

Background/aim: Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue.