Baicalein Nanofiber Scaffold Containing Hyaluronic Acid and Polyvinyl Alcohol: Preparation and Evaluation

Bachimam K., Emul E., SAĞLAM N., KORKUSUZ F.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.50, sa.4, ss.1139-1146, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-2001-123
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1139-1146
  • Anahtar Kelimeler: Baicalein, hyaluronic acid, nanofiber, electrospinning, bone cancer, tissue engineering, BONE, DIFFERENTIATION, OSTEOSARCOMA, ACTIVATION, MIGRATION, DELIVERY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background/aim: Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue.