Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

Pépin M., Klimkowicz-Mrowiec A., Godefroy O., Delgado P., Carriazo S., Ferreira A. C., ...Daha Fazla

European Journal of Neurology, cilt.30, sa.9, ss.2899-2911, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 9
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1111/ene.15928
  • Dergi Adı: European Journal of Neurology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.2899-2911
  • Anahtar Kelimeler: chronic kidney disease, cognition, dialysis, glomerular filtration rate, vascular risk factors
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition. Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives. Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce. Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.