Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis.

Park Y. H. , Remmers E. F. , Lee W., Ombrello A. K. , Chung L. K. , Zhao Shilei Z. S. , ...More

Nature immunology, vol.21, no.8, pp.857-867, 2020 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.1038/s41590-020-0705-6
  • Title of Journal : Nature immunology
  • Page Numbers: pp.857-867


Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues show that mutant pyrin better resists suppression by the plague bacteriumYersinia pestisand may have been positively selected in human Middle Eastern populations.