Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis.

Park Y. H. , Remmers E. F. , Lee W., Ombrello A. K. , Chung L. K. , Zhao Shilei Z. S. , ...Daha Fazla

Nature immunology, cilt.21, sa.8, ss.857-867, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1038/s41590-020-0705-6
  • Dergi Adı: Nature immunology
  • Sayfa Sayıları: ss.857-867

Özet

Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues show that mutant pyrin better resists suppression by the plague bacteriumYersinia pestisand may have been positively selected in human Middle Eastern populations.