Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis.

Park Y. H., Remmers E. F., Lee W., Ombrello A. K., Chung L. K., Zhao Shilei Z. S., ...More

Nature immunology, vol.21, no.8, pp.857-867, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.1038/s41590-020-0705-6
  • Journal Name: Nature immunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.857-867
  • Hacettepe University Affiliated: Yes

Abstract

Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues show that mutant pyrin better resists suppression by the plague bacteriumYersinia pestisand may have been positively selected in human Middle Eastern populations.