The role of SPINK5 in asthma related physiological events in the airway epithelium

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BİRBEN E., Sackesen C., TURGUTOĞLU N., Kalayci O.

RESPIRATORY MEDICINE, vol.106, no.3, pp.349-355, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 106 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1016/j.rmed.2011.11.007
  • Journal Name: RESPIRATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.349-355
  • Keywords: Apoptosis, Cytokine, Mucus production, Protease inhibitors, SPINK5, PROTEASE-ACTIVATED RECEPTOR-2, HUMAN LUNG FIBROBLASTS, SERINE-PROTEASE, ATOPIC-DERMATITIS, CELLS, INHIBITOR, INTERLEUKIN-8, INFLAMMATION, TRYPTASE, RELEASE
  • Hacettepe University Affiliated: Yes

Abstract

Background: Genetic studies have shown that variants in SPINK5 may be associated with atopic diseases and asthma. However, the functional role of SPINK5 protein in asthma has not been elucidated.