New 4(1H)-pyridinone derivatives as analgesic agents


Aytemir M. , UZBAY T., EROL D.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.49, ss.250-254, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 49 Konu: 3
  • Basım Tarihi: 1999
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Sayfa Sayıları: ss.250-254

Özet

A number of 2-methyl/ethyl-3-hydroxy-4(1H)-pyridinones have been synthesized by reacting with 4-pyrones and primary aromatic amines in ethanol. Their structures were confirmed by microanalysis, IR and H-1-NMR spectral analysis. Possible analgesic and anti-inflammatory activities of the synthesized compounds were investigated by acetic acid-induced writhing and carrageenan rat paw edema tests.