New 4(1H)-pyridinone derivatives as analgesic agents

Aytemir M., UZBAY T., EROL D.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.49, no.3, pp.250-254, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 1999
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.250-254
  • Hacettepe University Affiliated: Yes


A number of 2-methyl/ethyl-3-hydroxy-4(1H)-pyridinones have been synthesized by reacting with 4-pyrones and primary aromatic amines in ethanol. Their structures were confirmed by microanalysis, IR and H-1-NMR spectral analysis. Possible analgesic and anti-inflammatory activities of the synthesized compounds were investigated by acetic acid-induced writhing and carrageenan rat paw edema tests.