New 4(1H)-pyridinone derivatives as analgesic agents
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.49, no.3, pp.250-254, 1999 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 49 Issue: 3
- Publication Date: 1999
- Journal Name: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.250-254
- Hacettepe University Affiliated: Yes
Abstract
A number of 2-methyl/ethyl-3-hydroxy-4(1H)-pyridinones have been synthesized by reacting with 4-pyrones and primary aromatic amines in ethanol. Their structures were confirmed by microanalysis, IR and H-1-NMR spectral analysis. Possible analgesic and anti-inflammatory activities of the synthesized compounds were investigated by acetic acid-induced writhing and carrageenan rat paw edema tests.