Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients

Tunca, Zeliha; RESMI, Halil; ÖZKARA, HATİCE; Ciliv, Goenenc; CELTIKCI, BAŞAK; ALPTEKIN, Koksal; OZERDEM, Aysegul; AKDEDE, Berna; BAYKARA, Burak; BIRSOY, Bilge; ERGOR, Gul

doi:10.1016/j.pnpbp.2008.03.008

Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients

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Tunca Z., RESMI H., ÖZKARA H. A., Ciliv G., CELTIKCI B., ALPTEKIN K., ...More

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol.32, no.5, pp.1214-1220, 2008 (SCI-Expanded)

Publication Type: Article / Review
Volume: 32 Issue: 5
Publication Date: 2008
Doi Number: 10.1016/j.pnpbp.2008.03.008
Journal Name: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1214-1220
Hacettepe University Affiliated: Yes

Abstract

Dystonic movements and Parkinsonism are frequently seen in gangliosidoses and these conditions have been reported to modify dopaminergic plasticity. We investigated whether the activity of hexosaminidase, a type-two ganglioside (GM2) degrading enzyme, correlates with drug-induced extrapyramidal system (EPS) side effects in psychiatric patients. We compared hexosaminidase activity in the lymphocytes of 29 EPS-positive patients, 13 EPS-negative patients, and 30 healthy volunteers. The activities of A and B isoforms of hexosaminidase were higher in EPS-positive patients than EPS-negative patients and healthy controls. Multivariate analysis suggested an interaction with increased B isoform activity and EPS side effects in female bipolar disorder patients. Higher levels of hexosaminidase enzyme activity may explain the frequent occurrence of antipsychotic-induced extrapyramidal side effects in mood disorder patients. (C) 2008 Elsevier Inc. All rights reserved.