Augmentation of Antipsychotic Treatment with Memantine in Patients with Schizophrenia: A Systematic Review and Meta-Analysis

Vayisoglu S., KARAHAN S., ANIL YAĞCIOĞLU A. E.

TURK PSIKIYATRI DERGISI, vol.30, no.4, pp.253-259, 2019 (SSCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 30 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.5080/u23597
  • Journal Name: TURK PSIKIYATRI DERGISI
  • Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.253-259
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Many patients with schizophrenia respond partially to treatment with antipsychotic medications. A wide range of pharmaceutical agents are utilized as augmentation therapy in order to increase the efficacy of antipsychotic medication treatment. Memantine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist is one of these add-on agents. In this study we aimed to assess the efficacy of memantine augmentation by conducting a systematic review and meta-analysis on the psychopathology of patients with schizophrenia receving antipsychotic medication.