Achievements of Graphene and Its Derivatives Materials on Electrochemical Drug Assays and Drug-DNA Interactions

Imanzadeh H., Bakirhan N. K., KURALAY F., Amiri M., ÖZKAN S. A.

Critical Reviews in Analytical Chemistry, cilt.53, sa.6, ss.1263-1284, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 53 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/10408347.2021.2018568
  • Dergi Adı: Critical Reviews in Analytical Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Geobase, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1263-1284
  • Anahtar Kelimeler: direct electrochemistry, drug, drug-DNA interaction, Graphene, sensors
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Graphene, emerging as a true two-dimensional (2D) material, has attracted increasing attention due to its unique physical and electrochemical properties such as high surface area, excellent conductivity, high mechanical strength, and ease of functionalization and mass production. The entire scientific community recognizes the significance and potential impact of graphene. Electrochemical detection strategies have advantages such as being simple, fast, and low-cost. The use of graphene as an excellent interface for electrode modification provides a promising way to construct more sensitive and stable electrochemical (bio)sensors. The review presents sensors based on graphene and its derivatives for electrochemical drug assays from pharmaceutical dosage forms and biological samples. Future perspectives in this rapidly developing field are also discussed. In addition, the interaction of several important anticancer drug molecules with deoxyribonucleic acid (DNA) that was immobilized onto graphene-modified electrodes has been detailed in terms of dosage regulation and utility purposes.