THE GLYCOCALYX AND TRAUMA: A REVIEW

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Chignalia A., Yetimakman F., Christiaans S., Unal Ş., Bayrakci B., Wagener B., ...Daha Fazla

SHOCK, cilt.45, sa.4, ss.338-348, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1097/shk.0000000000000513
  • Dergi Adı: SHOCK
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.338-348
  • Anahtar Kelimeler: Endothelium, epithelium, glycocalyx, glypican, heparan sulfates, inflammation, pneumonia, syndecan, trauma, wounds, VENTILATOR-ASSOCIATED PNEUMONIA, BLOOD-FLOW RESISTANCE, ENDOTHELIAL GLYCOCALYX, LUNG INJURY, HEPARAN-SULFATE, SYMPATHOADRENAL ACTIVATION, CYTOSKELETAL REGULATION, PULMONARY INFLAMMATION, VASCULAR-PERMEABILITY, NEUTROPHIL MIGRATION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In the United States trauma is the leading cause of mortality among those under the age of 45, claiming approximately 192,000 lives each year. Significant personal disability, lost productivity, and long-term healthcare needs are common and contribute 580 billion dollars in economic impact each year. Improving resuscitation strategies and the early acute care of trauma patients has the potential to reduce the pathological sequelae of combined exuberant inflammation and immune suppression that can co-exist, or occur temporally, and adversely affect outcomes. The endothelial and epithelial glycocalyx has emerged as an important participant in both inflammation and immunomodulation. Constituents of the glycocalyx have been used as biomarkers of injury severity and have the potential to be target(s) for therapeutic interventions aimed at immune modulation. In this review, we provide a contemporary understanding of the physiologic structure and function of the glycocalyx and its role in traumatic injury with a particular emphasis on lung injury.