This study examined the effectiveness of a school-to-work transition skills program on the career adaptability and career optimism of senior year university students in Turkey. For this purpose, a career intervention program was adapted from one developed in the USA. Results indicated that participants in the intervention group (N = 16) had higher career adaptability and career optimism after the program, and their scores were higher than the control group (N = 16). The effectiveness of the program was confirmed by a follow-up test three months later. This study also discusses the theoretical and practical implications of career interventions in relation to the relevant literature.