In Vitro Biocompatibility of n-Type and Undoped Silicon Nanowires

Garipcan B., Odabas S., Demirel G., Burger J., Nonnenmann S. S. , Coster M. T. , ...More

ADVANCED ENGINEERING MATERIALS, vol.13, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 13
  • Publication Date: 2011
  • Doi Number: 10.1002/adem.200980045


The biocompatibility of undoped and n-type silicon nanowires (SiNWs), synthesized by metal-catalyzed chemical vapor deposition, was investigated in vitro, and compared with that for SiO(2)-coated silicon wafers. In cell interaction studies, L929 mouse fibroblast cells were used, in which MTT assay, AO/PI dye staining, cell proliferation/growth, and changes in cell adhesion/morphology on the surfaces were applied and investigated. Heamocompatibility of these materials were also tested. No significant cytotoxic effects were observed for either the undoped or for the n-type phosphorus-doped SiNWs. The cells on the nanowires exhibit high viability, normal nuclear, and morphological structure. They have shown no considerable negative blood response with respect to the control.