Anti-Inflammatory and Antinociceptive Potential of Major Phenolics from Verbascum salviifolium Boiss

Tatli İ. İ. , AKDEMİR Z. Ş. , YEŞİLADA E., Kuepeli E.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol.63, pp.196-202, 2008 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63
  • Publication Date: 2008
  • Doi Number: 10.1515/znc-2008-3-406
  • Title of Journal : Zeitschrift fur Naturforschung - Section C Journal of Biosciences
  • Page Numbers: pp.196-202


The potential effects of flavonoids, phenylethanoid and neolignan glycosides from the aerial parts of Verbascum salviifolium Boiss. were studied in the p-benzoquinone-induced writhing reflex, for the assessment of the antinociceptive activity, and in carrageenan- and PGE1-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced ear edema models in mice, for the assessment of the anti-inflammatory activity. Through bioassay-guided fractionation and isolation procedures ten compounds from the aqueous extract of the plant, luteolin 7-O-glucoside (1), luteolin 3′-O-glucoside (2), apigenin 7-O-glucoside (3), chrysoeriol 7-O-glucoside (4),β-hydroxyacteoside (5), martynoside (6), forsythoside B (7), angoroside A (8), dehydrodiconiferyl alcohol-9′-O-,β-D-glucopyranoside (9) and dehydrodiconiferyl alco-hol-9-O-β-D-glucopyranoside (10), were isolated and their structures were elucidated by spectral techniques. Results have shown that 1, 2, 3 and 5 significantly inhibited carrageenan-induced paw edema at a 200 mg/kg dose, while 1, 2 and 5 also displayed anti-inflammatory activity against the PGE1-induced hind paw edema model. However, all the compounds showed no effect in the TPA-induced ear edema model. The compounds 1 and 2 also exhibited significant antinociceptive activity. © 2008, Verlag der Zeitschrift für Naturforschung. All rights reserved.