Inflammation is a tissue response induced by infection. Especially chronic inflammation causing tissue damage is dangerous. The clinical findings show that inflammation leads to the formation of epithelial cancers and the initial phase of the inflammation-gene relationship is important. Infection causes 1/5 of all visceral tumors. Thinking that the infectious agents cause cancer, it is hoped that cancer can be prevented with antimicrobials. With the development of Human Papilloma Virus (HPV) vaccine, this hope has turned into reality.