Inhibition of Endoplasmic Reticulum Associated Degradation of Mutant Pro-beta Subunits of beta-Hexosaminidase by Kifunensine and Lactacystin


SINICI I. , Tropak M. B. , Oezkara H. A. , Mahuran D. J.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.34, ss.160-166, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 34 Konu: 3
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.160-166

Özet

Objectives: We investigated the stabilizing effects of inhibiting Endoplasmic Reticulum Associated Degradation using kifunensine and lactacystin on heterologous expression of two mutant pro-forms of beta-subunit of beta-hexosaminidase, 12 bp deletion and D208N missense mutations.