Challenges in Identifying Asthma Subgroups Using Unsupervised Statistical Learning Techniques

Prosperi M. C. F. , ŞAHİNER Ü. M. , Belgrave D., SAÇKESEN C. , Buchan I. E. , Simpson A., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.188, no.11, pp.1303-1312, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 188 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1164/rccm.201304-0694oc
  • Title of Journal : AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Page Numbers: pp.1303-1312
  • Keywords: asthma, children, clustering, machine learning, endotypes, CLUSTER-ANALYSIS, EXERCISE, CHILDREN, PHENOTYPES, MIXTURE, SELECTION, SYMPTOMS, TREE

Abstract

Rationale: Unsupervised statistical learning techniques, such as exploratory factor analysis (EFA) and hierarchical clustering (HC), have been used to identify asthma phenotypes, with partly consistent results. Some of the inconsistency is caused by the variable selection and demographic and clinical differences among study populations.