A correlation study of fluorouracil pharmacodynamics with clinical efficacy and toxicity


Esin E., Telli T. A. , YÜCE D. , YALÇIN Ş.

TUMORI J, cilt.104, ss.157-164, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 104 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5301/tj.5000652
  • Dergi Adı: TUMORI J
  • Sayfa Sayıları: ss.157-164

Özet

Purpose: Plasma 5-fluorouracil (5-FU) concentrations vary greatly between individuals who have received standard dosage. Pharmacokinetic adjusted doses have been hypothesized to overcome the possibility of potential toxicity and ineffectiveness related to inappropriate plasma levels of 5-FU. In this study, we prospectively investigated the clinical benefit and toxicity of 5-FU in relation to its pharmacokinetic properties.