A correlation study of fluorouracil pharmacodynamics with clinical efficacy and toxicity

Esin E., Telli T. A., YÜCE D., YALÇIN Ş.

TUMORI J, vol.104, no.3, pp.157-164, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 104 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.5301/tj.5000652
  • Journal Name: TUMORI J
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.157-164
  • Hacettepe University Affiliated: Yes

Abstract

Purpose: Plasma 5-fluorouracil (5-FU) concentrations vary greatly between individuals who have received standard dosage. Pharmacokinetic adjusted doses have been hypothesized to overcome the possibility of potential toxicity and ineffectiveness related to inappropriate plasma levels of 5-FU. In this study, we prospectively investigated the clinical benefit and toxicity of 5-FU in relation to its pharmacokinetic properties.