Comparison of extraarticular leakage values of radiopharmaceuticals used for radionuclide synovectomy

Gedik G., Ugur Ö. , Atilla B. , Pekmezci M., Yildirim M., Seven B., ...More

ANNALS OF NUCLEAR MEDICINE, vol.20, no.3, pp.183-188, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1007/bf03027428
  • Page Numbers: pp.183-188
  • Keywords: Y-90-citrate, Y-90-silicate, Re-186-sulfide, chronic synovitis, radionuclide synovectomy, RADIATION SYNOVECTOMY, RADIO SYNOVECTOMY, RADIOSYNOVIORTHESIS, SYNOVITIS, KNEE, Y-90, HEMOPHILIA, DOSIMETRY


Objectives: Radionuclide synovectomy is a reliable therapy in patients with chronic synovitis. However, radiation doses delivered to non-target organ systems due to leakage of radioactive material from the articular cavity are an important disadvantage of this procedure. In this study we compared extraarticular leakage values of the 3 commonly used radiopharmaceuticals; Y-90-citrate, Y-90-silicate and Re-186-sulfide colloid. Materials and Methods: Thirty-five patients with persistent synovitis were enrolled in the study. Twenty-two hemophilic, 8 rheumatoid arthritis and 5 patients with pigmented villonodular synovitis were studied. Y-90 labeled silicate and citrate were used for knee joints and 186Re-sulfide for intermediate sized joints. Radiocolloid leakage values were evaluated using a gamma camera with 20% window centered over the bremsstrahlung photopeak of Y-90 and a respective window over the 137 keV photopeak of Re-186. Regions of interest were drawn over the injection site, the regional lymph nodes and the background areas. Leakage of radiocolloid was calculated by dividing the counts/pixel in the regional lymph node area to the counts/pixel in the injection site. Results: No visible leakage was observed. The median leakage values calculated for Y-90-citrate, Y-90-silicate and Re-186-sulfide were found as 1.9%, 2.4% and 2.7%, respectively. The difference between the variability of leakage values was not statistically significant (p > 0.05). Conclusion: There was no significant difference in terms of extraarticular leakage between Y-90-citrate, Y-90-silicate and Re-186-sulfide radiocolloids.