An In Vitro Study on the Cytotoxicity and Genotoxicity of Silver Sulfide Quantum Dots Coated with Meso-2,3-dimercaptosuccinic Acid


Ozkan Vardar D., Aydin S. , Hocaoglu I., Yagci Acar H., Basaran N.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.16, no.3, pp.282-291, 2019 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.4274/tjps.galenos.2018.85619
  • Title of Journal : TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Page Numbers: pp.282-291

Abstract

Objectives: Silver sulfide (Ag2S) quantum dots (QDs) are highly promising nanomaterials in bioimaging systems due to their high activities for both imaging and drug/gene delivery. There is insufficient research on the toxicity of Ag2S QDs coated with meso-2,3-dimercaptosuccinic acid (DMSA). In this study, we aimed to determine the cytotoxicity of Ag2S QDs coated with DMSA in Chinese hamster lung fibroblast (V79) cells over a wide range of concentrations (5-2000 mu g/mL).