An In Vitro Study on the Cytotoxicity and Genotoxicity of Silver Sulfide Quantum Dots Coated with Meso-2,3-dimercaptosuccinic Acid

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Ozkan Vardar D., Aydin S., Hocaoglu I., Yagci Acar H., Basaran N.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.16, no.3, pp.282-291, 2019 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.4274/tjps.galenos.2018.85619
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.282-291
  • Keywords: Meso-2,3-dimercaptosuccinic acid coated silver sulfide quantum dots, genotoxicity, apoptosis, DNA-DAMAGE, CELL-LINES, PRISTINE NANOPARTICLES, HIGHLY LUMINESCENT, CARBON NANOTUBES, OXIDATIVE STRESS, V79 CELLS, TOXICITY, VIVO, TUMOR
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: Silver sulfide (Ag2S) quantum dots (QDs) are highly promising nanomaterials in bioimaging systems due to their high activities for both imaging and drug/gene delivery. There is insufficient research on the toxicity of Ag2S QDs coated with meso-2,3-dimercaptosuccinic acid (DMSA). In this study, we aimed to determine the cytotoxicity of Ag2S QDs coated with DMSA in Chinese hamster lung fibroblast (V79) cells over a wide range of concentrations (5-2000 mu g/mL).