An In Vitro Study on the Cytotoxicity and Genotoxicity of Silver Sulfide Quantum Dots Coated with Meso-2,3-dimercaptosuccinic Acid


Ozkan Vardar D., Aydin S. , Hocaoglu I., Yagci Acar H., Basaran N.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.16, ss.282-291, 2019 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16 Konu: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4274/tjps.galenos.2018.85619
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.282-291

Özet

Objectives: Silver sulfide (Ag2S) quantum dots (QDs) are highly promising nanomaterials in bioimaging systems due to their high activities for both imaging and drug/gene delivery. There is insufficient research on the toxicity of Ag2S QDs coated with meso-2,3-dimercaptosuccinic acid (DMSA). In this study, we aimed to determine the cytotoxicity of Ag2S QDs coated with DMSA in Chinese hamster lung fibroblast (V79) cells over a wide range of concentrations (5-2000 mu g/mL).