Stretchable poly(glycerol-sebacate)/beta-tricalcium phosphate composites with shape recovery feature by extrusion

Tevlek A., Agacik D. T., AYDIN H. M.

JOURNAL OF APPLIED POLYMER SCIENCE, vol.137, no.20, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 20
  • Publication Date: 2020
  • Doi Number: 10.1002/app.48689
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Applied Science & Technology Source, Biotechnology Research Abstracts, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: beta-TCP, composite, extrusion, Poly(glycerol-sebacate), shape memory, MECHANICAL-PROPERTIES, CELL BEHAVIOR, IN-VITRO, TISSUE, DEGRADATION, SCAFFOLDS, DESIGN, TCP
  • Hacettepe University Affiliated: Yes


There has been a great interest in research towards elastomers and their composites with an attempt to obtain the desired biological and mechanical response to scaffold materials in bone tissue engineering. Composites made of ceramic-thermoplastic mixtures have been shown success to deliver the inorganic component while fail to provide replacement of an elastic protein, that is, collagen, of the target bone tissue. Thus, in order to match up with the inherent elasticity of the native tissue, it is proposed an alternative to well-known thermoplastic-containing matrices by using a poly(glycerol-sebacate) (PGS)-beta-tricalcium phosphate elastomeric composite to offer flexibility and mechanical integrity. This study reports for the first time a successful extrusion of PGS containing biodegradable composites with shape-memory feature. The resulting structures are physically and chemically characterized. In vitro cell culture performance of the obtained materials is investigated by using an MC3T3-E1 mouse preosteoblast cell line. The materials obtained in this study can be shaped into the desired size and various forms via temperature stimuli. Resulting materials have been proposed for craniofacial tissue engineering as a bone filler in which surgeons need to shape biomaterials during the surgical procedure due to the complex geometry of the bones. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48689.