Risk factors for target non-attainment during empirical treatment with beta-lactam antibiotics in critically ill patients

De Waele J. J. , Lipman J., Akova M., Bassetti M., Dimopoulos G., Kaukonen M., ...More

INTENSIVE CARE MEDICINE, vol.40, no.9, pp.1340-1351, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 9
  • Publication Date: 2014
  • Doi Number: 10.1007/s00134-014-3403-8
  • Title of Journal : INTENSIVE CARE MEDICINE
  • Page Numbers: pp.1340-1351


Risk factors for beta-lactam antibiotic underdosing in critically ill patients have not been described in large-scale studies. The objective of this study was to describe pharmacokinetic/pharmacodynamic (PK/PD) target non-attainment envisioning empirical dosing in critically ill patients and considering a worst-case scenario as well as to identify patient characteristics that are associated with target non-attainment.