INTENSIVE CARE MEDICINE, cilt.40, sa.9, ss.1340-1351, 2014 (SCI-Expanded)
Risk factors for beta-lactam antibiotic underdosing in critically ill patients have not been described in large-scale studies. The objective of this study was to describe pharmacokinetic/pharmacodynamic (PK/PD) target non-attainment envisioning empirical dosing in critically ill patients and considering a worst-case scenario as well as to identify patient characteristics that are associated with target non-attainment.