Risk factors for target non-attainment during empirical treatment with beta-lactam antibiotics in critically ill patients


De Waele J. J. , Lipman J., Akova M., Bassetti M., Dimopoulos G., Kaukonen M., ...Daha Fazla

INTENSIVE CARE MEDICINE, cilt.40, ss.1340-1351, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s00134-014-3403-8
  • Dergi Adı: INTENSIVE CARE MEDICINE
  • Sayfa Sayıları: ss.1340-1351

Özet

Risk factors for beta-lactam antibiotic underdosing in critically ill patients have not been described in large-scale studies. The objective of this study was to describe pharmacokinetic/pharmacodynamic (PK/PD) target non-attainment envisioning empirical dosing in critically ill patients and considering a worst-case scenario as well as to identify patient characteristics that are associated with target non-attainment.