Risk factors for target non-attainment during empirical treatment with beta-lactam antibiotics in critically ill patients

De Waele, Jan; Lipman, J.; Akova, M.; Bassetti, M.; Dimopoulos, G.; Kaukonen, M.; Koulenti, D.; Martin, C.; Montravers, P.; Rello, J.; Rhodes, A.; Udy, A.; Starr, T.; Wallis, S.; Roberts, J.

doi:10.1007/s00134-014-3403-8

Risk factors for target non-attainment during empirical treatment with beta-lactam antibiotics in critically ill patients

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De Waele J. J. , Lipman J., Akova M., Bassetti M., Dimopoulos G., Kaukonen M., ...More

INTENSIVE CARE MEDICINE, vol.40, no.9, pp.1340-1351, 2014 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 40 Issue: 9
Publication Date: 2014
Doi Number: 10.1007/s00134-014-3403-8
Title of Journal : INTENSIVE CARE MEDICINE
Page Numbers: pp.1340-1351

Abstract

Risk factors for beta-lactam antibiotic underdosing in critically ill patients have not been described in large-scale studies. The objective of this study was to describe pharmacokinetic/pharmacodynamic (PK/PD) target non-attainment envisioning empirical dosing in critically ill patients and considering a worst-case scenario as well as to identify patient characteristics that are associated with target non-attainment.