Effect of Montelukast and MK-886 on Hepatic Ischemia-Reperfusion Injury in Rats

Daglar G., Karaca T., Yuksek Y. N., Gozalan U., AKBIYIK F., SÖKMENSÜER C., ...More

JOURNAL OF SURGICAL RESEARCH, vol.153, no.1, pp.31-38, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 153 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.02.052
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.31-38
  • Hacettepe University Affiliated: Yes

Abstract

Background. Hepatic ischemia-reperfusion injury (I/R) may occur in transplantation, trauma, and elective hepatic resections. Leukotrienes have been shown to play a major role in hepatic I/R injury. Five-lipoxygenase enzyme is an important enzyme in the production of leukotrienes from arachidonic acid. MK-886 is an inhibitor of 5-lipoxygenase, and montelukast is a cysteinyl leukotriene receptor antagonist. The aim of this study was to investigate whether MK-886 and montelukast are effective in. preventing hepatic I/R injury.