Effect of Montelukast and MK-886 on Hepatic Ischemia-Reperfusion Injury in Rats

Daglar G., Karaca T., Yuksek Y. N., Gozalan U., AKBIYIK F., SÖKMENSÜER C., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.153, sa.1, ss.31-38, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 153 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.jss.2008.02.052
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.31-38
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background. Hepatic ischemia-reperfusion injury (I/R) may occur in transplantation, trauma, and elective hepatic resections. Leukotrienes have been shown to play a major role in hepatic I/R injury. Five-lipoxygenase enzyme is an important enzyme in the production of leukotrienes from arachidonic acid. MK-886 is an inhibitor of 5-lipoxygenase, and montelukast is a cysteinyl leukotriene receptor antagonist. The aim of this study was to investigate whether MK-886 and montelukast are effective in. preventing hepatic I/R injury.